Environmental Epigenetics in Toxicology and Public Health (Volume 22) (Translational Epigenetics, Volume 22)

Environmental Epigenetics in Toxicology and Public Health (Volume 22) (Translational Epigenetics, Volume 22)

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance - Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification - Features contributions from international experts in the field "This is an important entry in the Translational Epigenetic series at a time that such methods are moving from a status of novel to practice and even translational. This beautifully illustrated volume in the series will likely become useful, if not essential, for two groups -- graduate students encountering the material for the first time and seasoned professionals, often researchers, who have read about these techniques and now wish to employ them. Given the emergence of this field, I don't believe many years will pass before a second edition is necessary. This is perhaps the most essential public health book I have reviewed in some time." --© Doody’s Review Service, 2021, John T. Pierce, MBBS(MD), reviewer, expert opinion Offers an in-depth discussion of the environmental determinants of epigenetic mechanisms in human development and disease Strong evidence exists that various environmental exposures can influence human health and disease both early and later in life. Increasingly, data from both in vivo and human population-based studies suggest that environmental influences affect a range of epigenetic mechanisms associated with human health and disease. In Environmental Epigenetics in Toxicology and Public Health , Dr. Rebecca Fry and over a dozen international contributors provide in-depth discussion of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. A volume in the Translational Epigenetics series, this book also aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Dr. Fry is Director of the Institute for Environmental Health Solutions and the Carol Remmer Angle Distinguished Professor in the Department of Environmental Sciences and Engineering at UNC-Chapel Hill. Her lab focuses on understanding how environmental exposures to toxic substances are associated with human disease. With a particular focus on genomic and epigenomic perturbations, her lab uses toxicogenomic and systems biology approaches to identify key molecular pathways that associate environmental exposure with diseases. A current focus in the lab is to study prenatal exposure to various environmental contaminants including arsenic, cadmium, and perflourinated chemicals. Dr. Fry aims to understand molecular mechanisms by which such early exposures are associated with long-term health effects in humans. Ultimately, Dr. Fry’s lab aims to identify mechanisms of contaminant-induced disease and the basis for inter-individual disease susceptibility. Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist i