Strategies to Modify the Drug Release from Pharmaceutical Systems (Woodhead Publishing Series in Biomedicine)

Strategies to Modify the Drug Release from Pharmaceutical Systems (Woodhead Publishing Series in Biomedicine)

Strategies to Modify the Drug Release from Pharmaceutical Systems, Second Edition serves as a vital reference on contemporary models aimed at achieving the precise therapeutic dosage and timing of drug release. The book provides updated strategies, mathematical models, routes of administration, and technologies, all presented succinctly and objectively. This six-chapter guide covers general concepts of drug release modification and classification of therapeutic systems, including passive versus active targeting. It delves into mechanisms to control drug release, discussing materials and technologies, and introduces mathematical and physicochemical models of drug release. Furthermore, it reviews drug delivery systems like 3D printing, nose-to-brain delivery, environmentally responsive systems, and new lipid systems, making it indispensable for pharmaceutical scientists, graduate students, materials scientists, and chemists. Includes up to date physicochemical principles and mathematical models - Covers new drug delivery systems such as 3D printed systems - Presents the advances in drug delivery from the past decade An up-to-date textbook and reference source with strategies to modify drug release that also considers new systems, technologies, and materials Strategies to Modify the Drug Release from Pharmaceutical Systems, Second Edition is a concise reference on the current models used to meet the required therapeutic dosage and time of release. Updated with new strategies, mathematical models, routes of administration, and technologies, the book's content is presented in a concise and objective way. The six chapters cover general concepts, modification of drug release, classification of therapeutics systems for drug delivery - including a thorough discussion of passive versus active targeting. Chapter four describes the main mechanisms to control drug release - including a broad discussion on materials and technologies. Chapter five discusses mathematical and physicochemical models of drug release, including new mechanistic models and their fitting. Chapter six ends the book with a comprehensive, yet concise, review of drug delivery systems including 3D printing, nose-to-brain, environmentally responsive systems, and new lipid systems. Strategies to Modify the Drug Release from Pharmaceutical Systems, 2nd Edition is the perfect reference for pharmaceutical scientists and graduate students looking for a complete and objective reference on drug release. Materials scientists and chemists can also benefit from the up-to-date overview of mathematical models applied to drug release. Marcos Luciano Bruschi, Ph.D., is Professor of Pharmaceutics and Pharmaceutical Technology in the Department of Pharmacy at the State University of Maringá (UEM), Paraná, Brazil. He gained a BSc in Pharmacy (1996 - UEM, Brazil), a MD in Pharmaceutical Sciences (2002 - State University of São Paulo - UNESP - Brazil) and a PhD in Pharmaceutical Sciences (2006 - University of São Paulo - USP - Brazil and School of Pharmacy, Queen’s University of Belfast, Northern Ireland, UK). In 2013-2014, he is accomplishing a Post-Doctoral Degree in Pharmaceutics in the School of Pharmacy, Queen’s University of Belfast (QUB - Northern Ireland, UK). He is registered with the Brazilian Pharmaceutical Society and, in 1998, took up a lectureship in Pharmaceutics in the School of Pharmacy, UEM, Brazil. In 1999, he was appointed as a senior lectureship and to a personal Chair in Pharmaceutics and Pharmaceutical Technology in 2006. His research concerns the development and characterization of pharmaceutical dosage forms and drug delivery systems, using natural or synthetic sources. Dr. Bruschi’s work has involved the development of novel drug delivery systems, with particular emphasis on micro/nanoparticles, semisolids, bio/mucoadhesives, thermoresponsive systems, liquid crystaline phases, and natural products. He is the author of three Brazilian patent requests and over 150 research papers/communications.